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KMID : 1123920140280010059
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 1 p.59 ~ p.62
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Effects of Fructus Piperis Longi Extracts on Glucose Uptake in Adipocyte
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Kim Mi-Seong
Kwon Kang-Beom
Song Je-Ho
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Abstract
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Glucose uptake plays a pivotal role in maintaining whole body glucose homeostasis in adipocytes and skeletal muscles. In the present study we have shown that Fructus Piperis Longi Extracts (FPLE) can stimulate glucose uptake in OP9 adipocytes. The increasing effects of FPLE on glucose uptake were inhibited by compound C pretreatment, which means that the glucose uptake effects by FPLE were carried out by AMP-activated protein kinase (AMPK) activation. Further studies revealed that FPLE stimulated glucose transport occurs through a mechanism involving extracellular signal-regulated kinase (ERK1/2) activation.
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KEYWORD
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Fructus Piperis Longi, glucose uptake, adipocytes
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